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Living machinesA handbook of research in biomimetics and biohybrid systems$
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Tony J. Prescott, Nathan Lepora, and Paul F.M.J Verschure

Print publication date: 2018

Print ISBN-13: 9780199674923

Published to Oxford Scholarship Online: June 2018

DOI: 10.1093/oso/9780199674923.001.0001

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Hippocampal memory prosthesis

Hippocampal memory prosthesis

(p.526) Chapter 55 Hippocampal memory prosthesis
Living machines

Dong Song

Theodore W. Berger

Oxford University Press

Damage to the hippocampus and surrounding regions of the medial temporal lobe can result in a permanent loss of the ability to form new long-term memories. Hippocampal memory prosthesis is designed to restore this ability. The animal model described here is the memory-dependent, delayed nonmatch-to-sample (DNMS) task in rats, and the core of the prosthesis is a biomimetic multi-input, multi-output (MIMO) nonlinear dynamical model that predicts hippocampal output (CA1) signals based on input (CA3) signals. When hippocampal CA1 function is pharmacologically blocked, successful DNMS behavior is abolished. However, when MIMO model predictions are used to re-instate CA1 memory-related activities with electrical stimulation, successful DNMS behavior and long-term memory function are restored. The hippocampal memory prosthesis has been successfully implemented in rodents and nonhuman primates, but the current system requires major advances before it can approach a working prosthesis. Looking forward, a deeper knowledge of neural coding will provide further insights.

Keywords:   hippocampus, spatio-temporal pattern, spike, memory, prostheses

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