Jump to ContentJump to Main Navigation
A Primer of Molecular Population Genetics$
Users without a subscription are not able to see the full content.

Asher D. Cutter

Print publication date: 2019

Print ISBN-13: 9780198838944

Published to Oxford Scholarship Online: August 2019

DOI: 10.1093/oso/9780198838944.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 07 December 2019

Case studies in molecular population genetics

Case studies in molecular population genetics

Genotype to phenotype to selection

Chapter:
(p.195) Chapter 9 Case studies in molecular population genetics
Source:
A Primer of Molecular Population Genetics
Author(s):

Asher D. Cutter

Publisher:
Oxford University Press
DOI:10.1093/oso/9780198838944.003.0009

Collections of DNA from nature for many individuals and loci give us the raw material for studying evolution at the molecular level. Chapter 9, “Case studies in molecular population genetics: genotype to phenotype to selection,” dives into several case studies of exciting real-world organisms that demonstrate the application from A to Z of the concepts developed throughout the book. It includes summaries of the natural context for each organism, ranging from armoring in fish (Eda, Pitx1) and color crypsis in mice (Mc1r) to butterfly flight ability (Pgi) and toxin metabolism in Drosophila fruit flies (Cyp6g1, Adh), then walks through the molecular data, their visualization, and their analysis. Complications and caveats to real-world analysis are discussed for how to identify demographic and selective effects in empirical datasets. The approaches include both candidate gene studies and genome scans, and show how different molecular population genetic analyses work in concert with one another. These population genetic analyses also can dovetail with functional molecular genetic experiments and with genetic mapping using crosses or genome-wide association study analysis. Chapter 9 ends by introducing a summary of several advanced topics in molecular population genetics, including concepts and tests for selection on standing variation, the genomic scale of data computation and evolutionary modelling, and connections to human evolution.

Keywords:   color adaptation, flight ability, insecticide resistance, body armor, alcohol tolerance

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .