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A Primer of Molecular Population Genetics$
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Asher D. Cutter

Print publication date: 2019

Print ISBN-13: 9780198838944

Published to Oxford Scholarship Online: August 2019

DOI: 10.1093/oso/9780198838944.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 15 December 2019

Quantifying genetic variation at the molecular level

Quantifying genetic variation at the molecular level

Chapter:
(p.34) Chapter 3 Quantifying genetic variation at the molecular level
Source:
A Primer of Molecular Population Genetics
Author(s):

Asher D. Cutter

Publisher:
Oxford University Press
DOI:10.1093/oso/9780198838944.003.0003

Chapter 3, “Quantifying genetic variation at the molecular level,” introduces quantitative methods for measuring variation directly in DNA sequences to help decipher fundamental properties of populations and what they can tell us about evolution. It provides an overview of the evolutionary factors that contribute to genetic variation, like mutational input, effective population size, genetic drift, migration rate, and models of migration. This chapter surveys the principal ways to measure and summarize polymorphisms within a single population and across multiple populations of a species, including heterozygosity, nucleotide polymorphism estimators of θ‎, the site frequency spectrum, and FST, and by providing illustrative natural examples. Populations are where evolution starts, after mutations arise as the spark of population genetic variation, and Chapter 3 describes how to quantify the variation to connect observations to predictions about how much polymorphism there ought to be under different circumstances.

Keywords:   genetic variation, effective population size, heterozygosity, nucleotide polymorphism, site frequency spectrum, genetic differentiation, gene flow, migration, genetic drift

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