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Epigenetics, Nuclear Organization & Gene Function - With implications of epigenetic regulation and genetic architecture for human development and health | Oxford Scholarship Online
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Epigenetics, Nuclear Organization & Gene Function: With implications of epigenetic regulation and genetic architecture for human development and health

John C. Lucchesi

Abstract

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. Epigenetic changes, consisting principally of DNA methylation, histone modifications and non-coding RNAs, maintain and modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. This book’s primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and its interdependence with genetic mechanisms. A further aim is to highlight the r ... More

Keywords: Epigenetics, chromatin, genome architecture, genetics, histone, covalent modification, remodeling, stem cell, aging, cancer

Bibliographic Information

Print publication date: 2019 Print ISBN-13: 9780198831204
Published to Oxford Scholarship Online: March 2019 DOI:10.1093/oso/9780198831204.001.0001

Authors

Affiliations are at time of print publication.

John C. Lucchesi, author
Asa Griggs Candler Professor Emeritus, Department of Biology, Emory University, Atlanta GA, USA

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Contents

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Part I An Introduction to Epigenetics and Epigenetic Regulation

Part II Transcription is Regulated by Epigenetic Mechanisms

Part IV Inheritance of Chromatin Structure and Functional States

End Matter