Jump to ContentJump to Main Navigation
Genes, brain, and emotionsInterdisciplinary and Translational Perspectives$
Users without a subscription are not able to see the full content.

Andrei C. Miu, Judith R. Homberg, and Klaus-Peter Lesch

Print publication date: 2019

Print ISBN-13: 9780198793014

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780198793014.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 26 January 2020

Psychosocial stress and telomere regulation

Psychosocial stress and telomere regulation

Chapter:
(p.247) Chapter 17 Psychosocial stress and telomere regulation
Source:
Genes, brain, and emotions
Author(s):

Idan Shalev

Waylon J Hastings

Publisher:
Oxford University Press
DOI:10.1093/oso/9780198793014.003.0017

Telomeres, the repetitive nucleoprotein regions at chromosome ends, are hallmarks of biological aging. Deficiencies in the network of proteins and nucleic acids which govern telomere regulation result in their gradual erosion over time, and shorter telomere length is associated with chronic disease as well as all-cause mortality. Telomeres are also indicative of cumulative stress experienced across the lifespan. This chapter summarizes empirical evidence for the impact of lifelong psychosocial stress, lifestyle behaviors, and chronic diseases on telomere biology. This biological embedding of experiences involves complex interactions with cellular processes regulating telomere length. Before describing such interactions, the chapter chronicles intrinsic regulation of telomeres by enzymatic, RNA, and epigenetic mechanisms. It then considers the stress-related mechanisms implicated in telomere regulation, including neuroendocrine systems, immuno-inflammation, oxidative stress, and mitochondrial respiration. A full understanding of these processes can promote better clinical treatments and intervention efforts to reverse the damaging effect of stress on telomeres.

Keywords:   psychosocial stress, telomeres, aging, telomerase, oxidative stress, molecular mechanisms

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .