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Textbook of Cancer Epidemiology$
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Hans-Olov Adami, David J. Hunter, Pagona Lagiou, and Lorelei Mucci

Print publication date: 2018

Print ISBN-13: 9780190676827

Published to Oxford Scholarship Online: February 2018

DOI: 10.1093/oso/9780190676827.001.0001

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Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma

Chapter:
(p.649) 27 Non-Hodgkin Lymphoma
Source:
Textbook of Cancer Epidemiology
Author(s):

Karin Ekström Smedby

Mads Melbye

Hans-Olov Adami

Publisher:
Oxford University Press
DOI:10.1093/oso/9780190676827.003.0027

Non-Hodgkin lymphomas (NHL) are a heterogeneous group of malignancies originating from B- or T-lymphocytes and engaging lymphoid tissue. Clinically, NHL subtypes range from chronic indolent to aggressive life-threatening diseases. The incidence of NHL overall increased dramatically worldwide during the latter half of the twentieth century but has now leveled off in many countries. Although some etiologic factors have been identified, most newly diagnosed cases of NHL as well as the previous rise in incidence remain largely unexplained. Well-established risk factors include severe immune suppression following HIV/AIDS and organ transplantation, autoimmune and inflammatory disorders, some infectious agents, and family history. More recently, lifestyle factors have also been linked with certain subtypes of NHL. Through the work of the international InterLymph consortium, several subtype-specific genetic susceptibility variants have also been revealed, promising to shed further light on mechanisms of lymphomagenesis.

Keywords:   non-Hodgkin lymphoma, B-cell malignancy, T-cell lymphoma, immune suppression, immune activation, genetic susceptibility, epidemiology, etiology

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