Jump to ContentJump to Main Navigation
Textbook of Cancer Epidemiology$
Users without a subscription are not able to see the full content.

Hans-Olov Adami, David J. Hunter, Pagona Lagiou, and Lorelei Mucci

Print publication date: 2018

Print ISBN-13: 9780190676827

Published to Oxford Scholarship Online: February 2018

DOI: 10.1093/oso/9780190676827.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 03 April 2020

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma

(p.649) 27 Non-Hodgkin Lymphoma
Textbook of Cancer Epidemiology

Karin Ekström Smedby

Mads Melbye

Hans-Olov Adami

Oxford University Press

Non-Hodgkin lymphomas (NHL) are a heterogeneous group of malignancies originating from B- or T-lymphocytes and engaging lymphoid tissue. Clinically, NHL subtypes range from chronic indolent to aggressive life-threatening diseases. The incidence of NHL overall increased dramatically worldwide during the latter half of the twentieth century but has now leveled off in many countries. Although some etiologic factors have been identified, most newly diagnosed cases of NHL as well as the previous rise in incidence remain largely unexplained. Well-established risk factors include severe immune suppression following HIV/AIDS and organ transplantation, autoimmune and inflammatory disorders, some infectious agents, and family history. More recently, lifestyle factors have also been linked with certain subtypes of NHL. Through the work of the international InterLymph consortium, several subtype-specific genetic susceptibility variants have also been revealed, promising to shed further light on mechanisms of lymphomagenesis.

Keywords:   non-Hodgkin lymphoma, B-cell malignancy, T-cell lymphoma, immune suppression, immune activation, genetic susceptibility, epidemiology, etiology

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .