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Textbook of Cancer Epidemiology$
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Hans-Olov Adami, David J. Hunter, Pagona Lagiou, and Lorelei Mucci

Print publication date: 2018

Print ISBN-13: 9780190676827

Published to Oxford Scholarship Online: February 2018

DOI: 10.1093/oso/9780190676827.001.0001

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Skin Cancer

Skin Cancer

(p.355) 15 Skin Cancer
Textbook of Cancer Epidemiology

Adèle C. Green

Catherine M. Olsen

David J. Hunter

Oxford University Press

Skin cancer is one of the few types of cancer for which exposure to the major carcinogen, solar ultraviolet (UV) radiation, is strongly implicated on the basis of descriptive epidemiologic data alone. There are three major forms of skin cancer considered in this chapter—melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC)—and each appears to have different causal relations to the pattern and total amount of sun exposure. High-intensity UV exposure and long-term UV exposure appear to be involved differentially in the various skin cancers and their subtypes. Underlying molecular mechanisms are becoming better understood, though many aspects like the cells of origin and the exact roles of intermediate lesions like actinic keratoses and nevi remain unclear. Because exposure of skin to UV radiation is modifiable, skin cancers are substantially preventable.

Keywords:   skin cancer, squamous cell cancer, basal cell cancer, melanoma, ultraviolet radiation

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