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Estrogens and MemoryBasic Research and Clinical Implications$
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Karyn M. Frick

Print publication date: 2020

Print ISBN-13: 9780190645908

Published to Oxford Scholarship Online: February 2020

DOI: 10.1093/oso/9780190645908.001.0001

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Estrogen Receptors at the Membrane

Estrogen Receptors at the Membrane

Interactions with Metabotropic Glutamate Receptors and Caveolin Proteins Regulated Through Palmitoylation

(p.24) 2 Estrogen Receptors at the Membrane
Estrogens and Memory

Katherine R. Tonn Eisinger

Paul G. Mermelstein

John Meitzen

Oxford University Press

Recent research has established that modified versions of classical estrogen receptors (ERs) act at the membrane to influence neuronal function. Specifically, palmitoylated ERα‎ and ERβ‎ stimulate signal transduction pathways from the membrane through transactivation of metabotropic glutamate receptors (mGluRs). Caveolin (Cav) proteins assemble mGluR and ER into functional signaling microdomains, with the pairing of specific mGluR and ER varying by brain region and Cav isoform. Palmitoylation regulates the trafficking, localization, and interaction of these proteins by allowing association with membrane lipid rafts. This chapter outlines the discovery that the same ERs responsible for nuclear signaling act at the plasma membrane to exert a wide array of effects. Membrane-associated ER signaling affects molecular, structural, and physiological states, leading to system-level changes in circuit dynamics and, ultimately, behavior.

Keywords:   estrogen receptor, mGluR, caveolin, palmitoylation, membrane-associated ER, lipid raft, rapid estrogen effects

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