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Estrogens and MemoryBasic Research and Clinical Implications$
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Karyn M. Frick

Print publication date: 2020

Print ISBN-13: 9780190645908

Published to Oxford Scholarship Online: February 2020

DOI: 10.1093/oso/9780190645908.001.0001

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Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus

Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus

(p.401) 23 Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus
Estrogens and Memory

Roshni D. Thakkar

Ruimin Wang

Gangadhara R. Sareddy

Ratna K. Vadlamudi

Darrell W. Brann

Oxford University Press

The steroid hormone 17β‎-estradiol (E2) is neuroprotective in several neurodegenerative conditions, including cerebral ischemia, traumatic brain injury, and Alzheimer’s disease (AD). This chapter focuses on the evidence supporting a neuroprotective role of E2 in the hippocampus in cerebral ischemia and AD and reviews various mechanisms thought to underlie E2-induced neuroprotection. Specifically, the chapter discusses the mechanistic role of (a) the various estrogen receptor subtypes, (b) genomic versus nongenomic signaling, (c) regulation of the prosurvival Wnt/β‎−catenin pathway, and (d) anti-inflammatory effects of E2 in the hippocampus. Finally, we also discuss the role of a novel estrogen receptor co-activator protein, proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) in mediating E2 genomic and non-genomic signaling, as well as the neuroprotective and cognitive-enhancing effects of E2 in the hippocampus.

Keywords:   estrogen, neuroprotection, signaling pathways, anti-inflammation, hippocampus

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