Jump to ContentJump to Main Navigation
Estrogens and MemoryBasic Research and Clinical Implications$
Users without a subscription are not able to see the full content.

Karyn M. Frick

Print publication date: 2020

Print ISBN-13: 9780190645908

Published to Oxford Scholarship Online: February 2020

DOI: 10.1093/oso/9780190645908.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 01 June 2020

Considerations on the Use of Aromatase Inhibitors in Postmenopausal Women With Breast Cancer

Considerations on the Use of Aromatase Inhibitors in Postmenopausal Women With Breast Cancer

Cognitive Function

Chapter:
(p.385) 22 Considerations on the Use of Aromatase Inhibitors in Postmenopausal Women With Breast Cancer
Source:
Estrogens and Memory
Author(s):

Jeffrey D. Blaustein

Publisher:
Oxford University Press
DOI:10.1093/oso/9780190645908.003.0023

About 1 of every 8 women will develop breast cancer during her lifetime, and approximately 250,000 new cancer cases are expected annually as of 2017. Of those breast cancers, approximately 60% to 75% will express estrogen receptors, suggesting that estrogens are likely to promote growth of those tumors. Because the use of inhibitors of the synthesis of estrogens is the adjuvant treatment of choice for many women, it is essential that we understand the potential adverse effects on quality of life of those treatments. This review addresses the role of estrogens locally synthesized in the brain in laboratory animals and women, the effects of estrogens on cognitive function, the effects of synthesis blockers on cognitive function, and the limitations in performing experiments that will give us strong confidence in the results and conclusions.

Keywords:   estrogens, estradiol, cognitive function, breast cancer, brain, aromatase, aromatase inhibitors

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .