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Estrogens and MemoryBasic Research and Clinical Implications$
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Karyn M. Frick

Print publication date: 2020

Print ISBN-13: 9780190645908

Published to Oxford Scholarship Online: February 2020

DOI: 10.1093/oso/9780190645908.001.0001

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Hormone Therapy in Postmenopausal Women

Hormone Therapy in Postmenopausal Women

The Women’s Health Initiative and Its Continuing Impact on Research and Practice

(p.337) 18 Hormone Therapy in Postmenopausal Women
Estrogens and Memory

Ira Driscoll

Stephen R. Rapp

Karen C. Johnson

Mark A. Espeland

Oxford University Press

Before 2002, hormone therapy (HT) was commonly prescribed to restore naturally diminishing hormonal levels during and after menopause. HT was also thought to prevent many health conditions faced by menopausal women, including osteoporosis, heart disease, cancer, and dementia. Support for these claims came primarily from epidemiological studies and basic research suggesting biological plausibility. Women now live a third of their life beyond ovarian function cessation. Given that cognitive impairment and dementia increase with age, increasing life expectancy may result in greater public health consequences. This chapter reviews the potential risks and benefits of HT, with a focus on cognitive function. It also discusses the implications of menopausal HT on cognitive impairment and dementia prevention, diagnosis, and treatment for aging women.

Keywords:   hormone therapy, cognition, aging, women’s health, dementia, estrogen

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