Jump to ContentJump to Main Navigation
Estrogens and MemoryBasic Research and Clinical Implications$
Users without a subscription are not able to see the full content.

Karyn M. Frick

Print publication date: 2020

Print ISBN-13: 9780190645908

Published to Oxford Scholarship Online: February 2020

DOI: 10.1093/oso/9780190645908.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 03 April 2020

Estrogenic Regulation of Synaptic Health and Cognition in Aging Rhesus Monkeys

Estrogenic Regulation of Synaptic Health and Cognition in Aging Rhesus Monkeys

Chapter:
(p.303) 17 Estrogenic Regulation of Synaptic Health and Cognition in Aging Rhesus Monkeys
Source:
Estrogens and Memory
Author(s):

Johanna L. Crimins

Yuko Hara

John H. Morrison

Publisher:
Oxford University Press
DOI:10.1093/oso/9780190645908.003.0018

A compelling case can be made for estrogen’s role in maintaining synaptic health in the context of cognitive aging. This chapter first reviews clinical literature pertinent to estrogenic actions on cognition in menopausal women. Next, the authors provide a comprehensive summary of recent investigations in aging rhesus monkeys, which have emerged as a particularly powerful model for the study of synaptic and cognitive effects of both natural and surgical menopause. In particular, we focus on hippocampal and dorsolateral prefrontal cortex neurons and circuits that degenerate in normal aging and Alzheimer’s disease. The responsiveness of these brain regions to estrogen and implications for their related memory systems are discussed. Finally, the chapter highlights work that needs to be done to more fully understand the molecular basis for the complex interplay between menopause, aging, and vulnerability to Alzheimer’s disease in higher cognitive function and synaptic health.

Keywords:   Area 46, dentate gyrus, working memory, 17-beta estradiol, hormone replacement therapy

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .