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Estrogens and MemoryBasic Research and Clinical Implications$
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Karyn M. Frick

Print publication date: 2020

Print ISBN-13: 9780190645908

Published to Oxford Scholarship Online: February 2020

DOI: 10.1093/oso/9780190645908.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 01 June 2020

Estrogenic Regulation of Hippocampal Neurogenesis Throughout the Lifespan

Estrogenic Regulation of Hippocampal Neurogenesis Throughout the Lifespan

(p.253) 15 Estrogenic Regulation of Hippocampal Neurogenesis Throughout the Lifespan
Estrogens and Memory

Shunya Yagi

Rand S. Eid

Wansu Qiu

Paula Duarte-Guterman

Liisa A. M. Galea

Oxford University Press

Neurogenesis in the hippocampus exists across a number of species, including humans. Steroid hormones, such as estrogens, modulate neurogenesis dependent on age, reproductive experience and sex. Findings are discussed in the chapter with reference to how neurogenesis in the hippocampus is related to learning and memory. Natural fluctuations in ovarian hormones or removal of ovaries modulate neurogenesis in the short term but not in the long term. Maternal experience has long-lasting effects on neurogenesis in the hippocampus. Acute estrogens increase proliferation in adult female rodents, but influence survival of new neurons dependent on a number of factors including sex, cognitive training, type of estrogen, and whether or not cells were produced under estrogens. This chapter outlines findings indicating that estrogens can be strong modulators of adult hippocampal neurogenesis, which may have implications for disorders involving hippocampal dysfunction that target women.

Keywords:   hippocampus, adult neurogenesis, dentate gyrus, cognition, sex differences, reproductive experience, aging, estrogen receptor

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