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Estrogens and MemoryBasic Research and Clinical Implications$
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Karyn M. Frick

Print publication date: 2020

Print ISBN-13: 9780190645908

Published to Oxford Scholarship Online: February 2020

DOI: 10.1093/oso/9780190645908.001.0001

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Ovarian Hormones, Cognition, and Reproductive Aging

Ovarian Hormones, Cognition, and Reproductive Aging

Applications and Implications for Translating Preclinical Endocrine Brain Research to the Clinic

Chapter:
(p.223) 14 Ovarian Hormones, Cognition, and Reproductive Aging
Source:
Estrogens and Memory
Author(s):

Alesia V. Prakapenka

Veronica L. Peña

Heather A. Bimonte-Nelson

Publisher:
Oxford University Press
DOI:10.1093/oso/9780190645908.003.0015

Increasing evidence has demonstrated that sex steroid hormones, such as estrogens and progestogens, impact nonreproductive behaviors such as cognitive function in women and nonhuman animals. In addition to cognitive alterations associated with the reproductive cycle in young females, endocrine changes in middle-aged and aged females can impact cognition in ways that may increase risk of dementia and neurodegenerative disease. As such, understanding how aging and reproductive senescence influence cognitive functions like memory, and whether hormone therapy can mitigate these effects, is extremely important to maintaining women’s mental health. This chapter reviews the endocrine changes that occur at reproductive senescence in women and rodents, describes rodent models of menopause and memory assessment and discusses the effects of various hormone therapies on learning and memory in aging females. Various factors influencing the effects of hormone therapy on cognition are discussed, as are considerations for future research.

Keywords:   estrogens, estrogen therapy, progestogens, memory, cognition, aging, menopause, reproductive senescence, animal models

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