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Estrogens and MemoryBasic Research and Clinical Implications$
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Karyn M. Frick

Print publication date: 2020

Print ISBN-13: 9780190645908

Published to Oxford Scholarship Online: February 2020

DOI: 10.1093/oso/9780190645908.001.0001

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Estrogenic Regulation of Recognition Memory and Spinogenesis

Estrogenic Regulation of Recognition Memory and Spinogenesis

Chapter:
(p.159) 10 Estrogenic Regulation of Recognition Memory and Spinogenesis
Source:
Estrogens and Memory
Author(s):

Victoria N. Luine

Maya Frankfurt

Publisher:
Oxford University Press
DOI:10.1093/oso/9780190645908.003.0011

This chapter reviews the relationship between estrogens, memory, and dendritic spine plasticity. Estrogens, given systemically or directly into the hippocampus, enhance memory consolidation in object recognition and object placement tasks within minutes of application. Dendritic spine density in the CA1 area of the hippocampus and medial prefrontal cortex increases under the same conditions, suggesting that changes in dendritic spine density are an important component of estrogen’s ability to impact memory processes. Possible receptors and signaling pathways mediating the molecular mechanisms in response to estrogen are discussed. Although the precise mechanisms remain to be elucidated, research to date suggests that modulation of dendritic spines by estradiol is a key component in promotion of memory consolidation.

Keywords:   estrogen, memory, dendritic spine, plasticity, object placement, object recognition, memory consolidation

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