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Estrogens and Memory – Basic Research and Clinical Implications - Oxford Scholarship Online
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Estrogens and Memory: Basic Research and Clinical Implications

Karyn M. Frick

Abstract

Although estrogens are best known for their roles in reproduction, they are also key modulators of brain regions that mediate learning and memory formation. This regulation has significant translational implications, as estrogens contribute to age-related memory decline and dementia, emotional disorders, addiction, and recovery from brain injury. Although the importance of estrogens for memory formation has been well accepted within the behavioral neuroendocrinology community, they have yet to be fully appreciated by neuroscientists outside of the discipline. The majority of researchers are no ... More

Keywords: estrogens, learning, memory, menopause, aging, brain, hippocampus, cognition, synaptic plasticity, Alzheimer’s disease

Bibliographic Information

Print publication date: 2020 Print ISBN-13: 9780190645908
Published to Oxford Scholarship Online: February 2020 DOI:10.1093/oso/9780190645908.001.0001

Authors

Affiliations are at time of print publication.

Karyn M. Frick, editor
Professor of Psychology, University of Wisconsin-Milwaukee

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Contents

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Part I Estrogen Effects on the Hippocampus and Related Brain Regions

1 Estrogen Receptor Distribution in the Hippocampus and Prefrontal Cortex

Annelyn Torres-Reveron, Wayne G. Brake, and Teresa A. Milner

2 Estrogen Receptors at the Membrane

Katherine R. Tonn Eisinger, Paul G. Mermelstein, and John Meitzen

3 Rapid Effects of Estradiol on Dendritic Spines and Synaptic Plasticity in the Male and Female Hippocampus

Asami Kato, Gen Murakami, Yasushi Hojo, Sigeo Horie, and Suguru Kawato

4 Rapid Modulation of Spinogenesis by Estradiol in the Neocortex

Deepak P. Srivastava, Katherine J. Sellers, and Peter D. Evans

7 Estrogenic Regulation of Glia and Neuroinflammation

Andrea Crespo-Castrillo, Maria Angeles Arevalo, Luis M. Garcia-Segura, and Natalia Yanguas-Casás

Part II Estrogenic Regulation of Memory and Related Cognitive Processes Throughout the Lifespan

8 Molecular Mechanisms Underlying Rapid Effects of Estradiol on Memory Consolidation

Karyn M. Frick, Jaekyoon Kim, Wendy A. Koss, and Jennifer J. Tuscher

9 Estrogenic Regulation of Spatial Memory in Songbirds

David J. Bailey and Colin J. Saldanha

11 Who Are You and What Do You Know?

Paul A. S. Sheppard, Talya Kuun, Pietro Paletta, and Elena Choleris

13 Puberty

Janice M. Juraska

14 Ovarian Hormones, Cognition, and Reproductive Aging

Alesia V. Prakapenka, Veronica L. Peña, and Heather A. Bimonte-Nelson

15 Estrogenic Regulation of Hippocampal Neurogenesis Throughout the Lifespan

Shunya Yagi, Rand S. Eid, Wansu Qiu, Paula Duarte-Guterman, and Liisa A. M. Galea

17 Estrogenic Regulation of Synaptic Health and Cognition in Aging Rhesus Monkeys

Johanna L. Crimins, Yuko Hara, and John H. Morrison

Part III Translational Implications of Estrogenic Regulation of Memory for Aging and Disease

18 Hormone Therapy in Postmenopausal Women

Ira Driscoll, Stephen R. Rapp, Karen C. Johnson, and Mark A. Espeland

19 Estrogen Treatment in Alzheimer’s Disease

Kelly N. Morgan and Carey E. Gleason

20 Effects of Dietary Estrogens on Dementia

Shelina Kassam and Eef Hogervorst

21 Oral Contraceptive Effects on Cognition

Soniya Assudani Patel, Courtney McQuade, and Robert S. Astur

23 Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus

Roshni D. Thakkar, Ruimin Wang, Gangadhara R. Sareddy, Ratna K. Vadlamudi, and Darrell W. Brann

25 Estradiol and Sex Differences in Generalized Fear

Jordan M. Adkins, Aaron M. Jasnow, and Joseph F. Lynch III

Part IV Conclusions and Future Directions

27 Moving Forward

Karyn M. Frick

End Matter