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Codon EvolutionMechanisms and Models$
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Gina M. Cannarozzi and Adrian Schneider

Print publication date: 2012

Print ISBN-13: 9780199601165

Published to Oxford Scholarship Online: May 2015

DOI: 10.1093/acprof:osobl/9780199601165.001.0001

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The application of population genetics in the study of codon usage bias

The application of population genetics in the study of codon usage bias

Chapter:
(p.245) Chapter 16 The application of population genetics in the study of codon usage bias
Source:
Codon Evolution
Author(s):

Kai Zeng

Publisher:
Oxford University Press
DOI:10.1093/acprof:osobl/9780199601165.003.0016

This chapter examines codon usage bias, particularly synonymous polymorphisms, from a population genetic point of view. It describes the two most widely used models in the study of synonymous polymorphism data: the reversible mutation model and the infinite sites model, with an emphasis on the similarities and differences between these models. It also discusses some recent extensions to the original models. Several examples of the application of these models to Drosophila melanogaster are provided.

Keywords:   codon usage bias, synonymous polymorphisms, population genetics, reversible mutation model, infinite sites model, Drosophila melanogaster

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