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Immune Responses in the Nervous System$
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Nancy J. Rothwell

Print publication date: 1997

Print ISBN-13: 9781872748795

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9781872748795.001.0001

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The immunology of brain injury

The immunology of brain injury

Chapter:
(p.159) Chapter 8 The immunology of brain injury
Source:
Immune Responses in the Nervous System
Author(s):

Maria Cristina Morganti-kossmann

Thomas Kossmann

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9781872748795.003.0008

The central nervous system (CNS) is regarded as an immunologically privileged site due to its separation from the periphery mediated by the blood-brain barrier. Despite this barrier, immunological reactions can occur within the CNS during disease and injury. Characterization of the cells, mediators and other factors participating in the immunological processes within the brain, as well as the interaction of immune-competent cells of the CNS with the systemic immune system, has been the focus of ongoing research. This chapter reviews the immune functions of glial cells, in particular their ability to produce immune mediators and to interact with their systemic counterparts in pathology and injury of the brain.

Keywords:   central nervous system, glial cells, immune functions, immune mediators

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