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Immune Responses in the Nervous System$
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Nancy J. Rothwell

Print publication date: 1997

Print ISBN-13: 9781872748795

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9781872748795.001.0001

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Leukocyte migration into the central nervous system

Leukocyte migration into the central nervous system

(p.27) Chapter 2 Leukocyte migration into the central nervous system
Immune Responses in the Nervous System

Linda J. Lawson

Oxford University Press

The entry of leukocytes into tissue is a fundamental process in the host's response to injury or infection. Limitations on the entry of leukocytes into the central nervous system are one aspect of the ‘immunological privilege’ of the brain. In both the normal and injured brain, leukocyte recruitment is more restricted than under similar conditions in non-CNS tissues. Discovering how the CNS regulates leukocyte recruitment would broaden our understanding of the role of the tissue microenvironment in modulating inflammatory and immune responses. This chapter discusses the study of leukocyte migration into the brain, mononuclear phagocytes, the inflamed brain, lymphocytes, and the problems of entering the brain.

Keywords:   leukocytes, central nervous system, immunological privilege, normal brain, injured brain, mononuclear phagocytes, lymphocytes

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