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Immune Responses in the Nervous System$
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Nancy J. Rothwell

Print publication date: 1997

Print ISBN-13: 9781872748795

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9781872748795.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 15 November 2019

The blood–brain barrier and perivascular cells

The blood–brain barrier and perivascular cells

Chapter:
(p.1) Chapter 1 The blood–brain barrier and perivascular cells
Source:
Immune Responses in the Nervous System
Author(s):

Barbro B. Johansson

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9781872748795.003.0001

This chapter discusses the blood-brain (BBB) barrier and perivascular cells. The BBB is a dynamic and complex interface between blood and brain enabling an optimal internal environment for neurons and glial cells. It is uncertain if cytokines enter the brain from the blood. Whatever the signaling mechanisms, it is clear that peripheral cytokines can influence the brain and that cytokines can be released by microglia and other cells, including brain endothelial cells, thereby enhancing passage of leukocytes and macrophages into the brain. The role of neutrophils and macrophages in the pathomechanism of the BBB alteration, edema formation, and cell damage in meningitis, trauma, and vascular lesions needs further evaluation.

Keywords:   neurons, glial cells, cytokines, leukocytes, macrophages, neutrophils

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