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Losing Our MindsEffects of Chemical Pollution on the Intellectual Capacity and Mental Health of Future Generations$
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Barbara Demeneix

Print publication date: 2014

Print ISBN-13: 9780199917518

Published to Oxford Scholarship Online: August 2014

DOI: 10.1093/acprof:oso/9780199917518.001.0001

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Mixtures and Low Doses

Mixtures and Low Doses

The Complexity of Risk Assessment

Chapter:
(p.179) Chapter 6 Mixtures and Low Doses
Source:
Losing Our Minds
Author(s):

Barbara Demeneix

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199917518.003.0006

The current EPA Toxic Substance Control Act (TSCA) inventory lists over 84,000 chemicals manufactured or imported into the United States in quantities above 10 tons. This list does not include substances covered by other legislations such as pesticides, foodstuffs, or food additives and cosmetics. Given that many of these substances are released into the environment, it is hardly surprising to find that each one of us is contaminated with dozens of them. Even more disquieting are the reports showing that amniotic fluid, umbilical cord blood, and breast milk are also cocktails of contaminants. Thus, the most vulnerable periods of life are played out in an unprecedented mixture of chemical compounds of industrial origin. Although many of these substances are present at low doses, there are very little data on the effects of these multiple low-dose mixtures on developmental processes.

Keywords:   chemical cocktails, dose–response curves, low doses, physiological responses, nonmonotonic

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