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Losing Our MindsEffects of Chemical Pollution on the Intellectual Capacity and Mental Health of Future Generations$
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Barbara Demeneix

Print publication date: 2014

Print ISBN-13: 9780199917518

Published to Oxford Scholarship Online: August 2014

DOI: 10.1093/acprof:oso/9780199917518.001.0001

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Thyroid Hormone Signaling as a Target of Multiple Pollutants

Thyroid Hormone Signaling as a Target of Multiple Pollutants

Chapter:
(p.89) Chapter 4 Thyroid Hormone Signaling as a Target of Multiple Pollutants
Source:
Losing Our Minds
Author(s):

Barbara Demeneix

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199917518.003.0004

This chapter provides a physiological framework for understanding why chemicals that interfere with thyroid hormone (TH) signaling are such a cause for concern. TH production, distribution, metabolism, entry into cells, and activation are explained. Each can be a target of chemical disruption. Initial focus is placed on development of the hypothalamic/pituitary axis that regulates the production of TH by the thyroid gland, identifying components or mechanisms that could be targets of disruption. The second idea is the complexity of the thyroid gland itself and the many processes required for uptake and incorporation of iodine into TH. A third consideration is the large number of proteins with which TH interacts as it is distributed through the body, taken up by and then activated or metabolized within target cells.

Keywords:   thyroid hormone synthesis, production, metabolism, distribution, TH

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