Jump to ContentJump to Main Navigation
Brain Aromatase, Estrogens, and Behavior$
Users without a subscription are not able to see the full content.

Jacques Balthazart and Gregory Ball

Print publication date: 2012

Print ISBN-13: 9780199841196

Published to Oxford Scholarship Online: January 2013

DOI: 10.1093/acprof:oso/9780199841196.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 19 October 2019

Molecular Mechanisms Controlling Brain Aromatase Expression

Molecular Mechanisms Controlling Brain Aromatase Expression

Chapter:
(p.138) Chapter 8 Molecular Mechanisms Controlling Brain Aromatase Expression
Source:
Brain Aromatase, Estrogens, and Behavior
Author(s):

Nobuhiro Harada

Shin-ichiro Honda

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199841196.003.0008

Aromatase is expressed not only in gonadal tissues but also in nongonadal tissues including the brain, and participates in various tissue-specific functions through local production of estrogens. To control diverse physiological functions in various tissues, aromatase has a unique gene structure with multiple exons 1 and promoters that are used in a tissue-specific manner. The transcriptional regulation of aromatase expression is mediated by binding of tissue-specific transcription factors or hormones to their responsive elements on each promoter to activate or repress the transcriptional machinery. Possible regulatory factors/hormones, transcription factors, and DNA responsive elements involved in the tissue-specific expression of aromatase are reviewed in this chapter.

Keywords:   alternative splicing, DNase footprinting, gel shift assay, hypothalamus, multiple exon 1 variants, perinatal period, promoter activity, responsive element, tissue-specific expression, transcription factor

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .