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Brain Aromatase, Estrogens, and Behavior$
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Jacques Balthazart and Gregory Ball

Print publication date: 2012

Print ISBN-13: 9780199841196

Published to Oxford Scholarship Online: January 2013

DOI: 10.1093/acprof:oso/9780199841196.001.0001

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Brain Aromatase in Fishes: Historical Perspective and Comparative Approaches

Brain Aromatase in Fishes: Historical Perspective and Comparative Approaches

Chapter:
(p.13) Chapter 2 Brain Aromatase in Fishes: Historical Perspective and Comparative Approaches
Source:
Brain Aromatase, Estrogens, and Behavior
Author(s):

Gloria V. Callard

Sarah R. Greytak

Apolonia Novillo

Kellie A. Cotter

Rebecca K. Meyer

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199841196.003.0002

The ability to convert androgens to estrogens is an ancient and highly conserved characteristic of the vertebrate brain but is lacking in amphioxus and all other invertebrates, indicating that a functional form of the enzyme first evolved in the brain of a basal jawed vertebrate (∼400 million years ago, mya), not long after its origin in the urogenital ridge of a common vertebrate ancestor (∼500 mya). This chapter reviews the history of fishes in brain aromatase research, specifically, their utility as laboratory models for advancing our understanding of the basic biology of neural aromatase; and the applicability of the predominant brain form of aromatase in fishes as a biomarker of general reproductive health and an indicator of pollutants in the natural environment.

Keywords:   aromatases, CYP19A, CYP19B, estrogen synthesis, fishes

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