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Brain Aromatase, Estrogens, and Behavior$
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Jacques Balthazart and Gregory Ball

Print publication date: 2012

Print ISBN-13: 9780199841196

Published to Oxford Scholarship Online: January 2013

DOI: 10.1093/acprof:oso/9780199841196.001.0001

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Brain Aromatase and Neuroprotection in Mammals

Brain Aromatase and Neuroprotection in Mammals

Chapter:
(p.371) Chapter 19 Brain Aromatase and Neuroprotection in Mammals
Source:
Brain Aromatase, Estrogens, and Behavior
Author(s):

Iñigo Azcoitia

Maria Angeles Arevalo

Luis Miguel Garcia-Segura

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199841196.003.0019

Recent studies suggest that, at least under neurodegenerative conditions, local brain formation of estradiol by the enzyme aromatase is an endogenous neuroprotective mechanism. This chapter reviews neuroprotective actions of aromatase and local estradiol synthesis in different experimental models of brain pathology in mammals. The cell types involved in the production of aromatase after brain injury, the role of neurogenesis and synaptic plasticity in the mechanisms of neuroprotection, the consequences of aromatase deficiency for brain function, and the possible implication of brain aromatase in the generation of sex differences in brain pathology are also discussed.

Keywords:   Alzheimer’s disease, brain injury, cerebellar ataxia, chronic hypertension, estradiol, neurodegeneration, neurogenesis, Parkinson’s disease, stroke, synaptic plasticity

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