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Does Aging Stop?$
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Laurence D. Mueller, Casandra L. Rauser, and Michael R. Rose

Print publication date: 2011

Print ISBN-13: 9780199754229

Published to Oxford Scholarship Online: September 2011

DOI: 10.1093/acprof:oso/9780199754229.001.0001

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Genetics of Late Life Involve Antagonistic Pleiotropy

Genetics of Late Life Involve Antagonistic Pleiotropy

(p.56) 5 Genetics of Late Life Involve Antagonistic Pleiotropy
Does Aging Stop?

Laurence D. Muller

Oxford University Press

Reverse evolution experiments implicate antagonistic pleiotropy in the evolution of both mortality and fecundity during late life. Hybridization experiments do not implicate mutation accumulation in the evolution of late life, but do not necessarily preclude its involvement.

Keywords:   reverse evolution, antagonistic pleiotropy, mutation accumulation, hybridization

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