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Restorative Neurology of Spinal Cord Injury$
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Milan R. Dimitrijevic, Byron A. Kakulas, W. Barry McKay, and Gerta Vrbova

Print publication date: 2011

Print ISBN-13: 9780199746507

Published to Oxford Scholarship Online: January 2012

DOI: 10.1093/acprof:oso/9780199746507.001.0001

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Neural Control of Locomotion

Neural Control of Locomotion

(p.65) 4 Neural Control of Locomotion
Restorative Neurology of Spinal Cord Injury

Gerta Vrbová

Urszula Sławin´ska

Henryk Majczyn´ski

Oxford University Press

This chapter presents animal models of spinal cord injury (SCI) and discusses how an understanding of the mechanisms responsible for producing the locomotor pattern, rhythmic limb movements associated with locomotion, is useful for the development of interventions to repair the damaged spinal cord. It reviews the work performed in cat and rat models of SCI describing the contributions of supraspinal, spinal, and peripheral neural circuitry to the generation of spinal motor output, organized to perform functional standing and stepping movements. The review includes models of complete transaction, selective focal lesions, and generalized diffuse injury, and covers the effects of a wide array of ablative and pharmacological manipulations. Finally, the chapter considers what is known about the different neurotransmitter systems at work in the spinal neural circuitry and how they are impacted by SCI.

Keywords:   animal models, spinal cord injury, locomotion, spinal neural circuitry, spinal motor output

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