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Engineering the Next Revolution in NeuroscienceThe New Science of Experiment Planning$
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Alcino J. Silva, Anthony Landreth, and John Bickle

Print publication date: 2013

Print ISBN-13: 9780199731756

Published to Oxford Scholarship Online: January 2014

DOI: 10.1093/acprof:oso/9780199731756.001.0001

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The Power of Convergence

The Power of Convergence

Chapter:
(p.42) [4] The Power of Convergence
Source:
Engineering the Next Revolution in Neuroscience
Author(s):

Alcino J. Silva

Anthony Landreth

John Bickle

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199731756.003.0004

In molecular and cellular cognition, there are three types of experiments that can be carried out to test whether A causes B (A→B): The magnitude of A can either be (1) increased or (2) decreased, and the impact on B measured, or (3) A and B can be measured without being intentionally altered to determine if they co-vary. A distinctive pattern of convergent evidence, referred to as the Convergent 3, emerges when these three kinds of experiments are consistent with a single hypothesis. In this chapter, the Convergent 3 Integration analysis is illustrated in action with learning and memory experiments focusing on the role of calmodulin kinase II in plasticity and learning.

Keywords:   Experiment, causation, hippocampus, learning, memory, long-term potentiation, calmodulin kinase II

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