There is a great need to develop scientific principles and tools that help scientists navigate the overwhelming size and complexity of the scientific literature. This is a considerable problem not only for efforts to understand the content and implications of the published record but also for research planning. The chapter outlines a framework and a set of principles for tackling the vexing complexity of the scientific literature. It also introduces the field (molecular and cellular cognition) used for the case studies that illustrate the approaches developed in the book.
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