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Teaching EpidemiologyA guide for teachers in epidemiology, public health and clinical medicine$
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Jørn Olsen, Naomi Greene, Rodolfo Saracci, and Dimitrios Trichopoulos

Print publication date: 2015

Print ISBN-13: 9780199685004

Published to Oxford Scholarship Online: June 2015

DOI: 10.1093/acprof:oso/9780199685004.001.0001

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Clinical epidemiology

Clinical epidemiology

Chapter:
(p.444) Chapter 24 Clinical epidemiology
Source:
Teaching Epidemiology
Author(s):

John A. Baron

Henrik Toft Sørensen

Harold C. Sox

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199685004.003.0024

Clinical epidemiology is the application of quantitative techniques to clinical issues such as diagnosis, treatment, and assessment of disease risk and prognosis. The discipline relies heavily on basic concepts of biostatistics and epidemiology, and these are applied in a clinical context to provide an evidence base for clinical care. Additional important methodological tools include concepts of validity and precision, measures of agreement and disagreement, and survival analysis. These are used to measure disease occurrence and prognosis, assess variability in medical information, and develop, validate, and apply clinical scales and prediction rules. Clinical trials involve the concepts of randomization, unbiased outcome assessment, and the intention-to-treat analysis. Quantitative approaches to diagnosis and testing and expected value decision analysis are topics unique to clinical epidemiology. Screening and prevention are also important, requiring an understanding of concepts such as lead time and length-biased sampling as well as appropriate measures of benefit.

Keywords:   clinical epidemiology, clinical trials, diagnosis, decision analysis, screening

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