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Handbook of Cannabis$
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Roger Pertwee

Print publication date: 2014

Print ISBN-13: 9780199662685

Published to Oxford Scholarship Online: January 2015

DOI: 10.1093/acprof:oso/9780199662685.001.0001

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Cannabinoid Pharmacokinetics and Disposition in Alternative Matrices

Cannabinoid Pharmacokinetics and Disposition in Alternative Matrices

Chapter:
(p.296) Chapter 16 Cannabinoid Pharmacokinetics and Disposition in Alternative Matrices
Source:
Handbook of Cannabis
Author(s):

Marilyn A. Huestis

Michael L. Smith

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199662685.003.0016

Knowledge of cannabinoid pharmacokinetics and cannabinoid disposition into biological fluids and tissues is essential to understanding the onset, magnitude, and duration of cannabinoid pharmacodynamic effects. Controlled cannabinoid administration studies simultaneously collecting pharmacodynamic and pharmacokinetic data provide the scientific basis for interpreting cannabinoid results and development of evidence-based drug policy and legislation. Also, when evaluating drug interactions, it is necessary to determine if the interaction is due to pharmacodynamic or pharmacokinetic effects. There is great value in quantifying different cannabinoid analytes in blood, urine, oral fluid, sweat, and hair to improve interpretation of cannabinoid results. Each biological matrix provides unique data about the individual’s drug intake. Selection of the best matrix, analytes to monitor, and cutoff concentrations can optimize the value of drug testing. Prediction models derived from controlled cannabinoid administration studies estimating time of last drug use also are available to improve interpretation of blood and urine cannabinoid results.

Keywords:   cannabinoids, pharmacokinetics, alternative matrices, blood, urine, oral fluid, sweat, hair, prediction models, drug testing

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