Jump to ContentJump to Main Navigation
Handbook of Cannabis$
Users without a subscription are not able to see the full content.

Roger Pertwee

Print publication date: 2014

Print ISBN-13: 9780199662685

Published to Oxford Scholarship Online: January 2015

DOI: 10.1093/acprof:oso/9780199662685.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 12 July 2020

Cannabinoid Pharmacokinetics and Disposition in Alternative Matrices

Cannabinoid Pharmacokinetics and Disposition in Alternative Matrices

(p.296) Chapter 16 Cannabinoid Pharmacokinetics and Disposition in Alternative Matrices
Handbook of Cannabis

Marilyn A. Huestis

Michael L. Smith

Oxford University Press

Knowledge of cannabinoid pharmacokinetics and cannabinoid disposition into biological fluids and tissues is essential to understanding the onset, magnitude, and duration of cannabinoid pharmacodynamic effects. Controlled cannabinoid administration studies simultaneously collecting pharmacodynamic and pharmacokinetic data provide the scientific basis for interpreting cannabinoid results and development of evidence-based drug policy and legislation. Also, when evaluating drug interactions, it is necessary to determine if the interaction is due to pharmacodynamic or pharmacokinetic effects. There is great value in quantifying different cannabinoid analytes in blood, urine, oral fluid, sweat, and hair to improve interpretation of cannabinoid results. Each biological matrix provides unique data about the individual’s drug intake. Selection of the best matrix, analytes to monitor, and cutoff concentrations can optimize the value of drug testing. Prediction models derived from controlled cannabinoid administration studies estimating time of last drug use also are available to improve interpretation of blood and urine cannabinoid results.

Keywords:   cannabinoids, pharmacokinetics, alternative matrices, blood, urine, oral fluid, sweat, hair, prediction models, drug testing

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .