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A Life Course Approach to Mental Disorders$
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Karestan C. Koenen, Sasha Rudenstine, Ezra Susser, and Sandro Galea

Print publication date: 2013

Print ISBN-13: 9780199657018

Published to Oxford Scholarship Online: January 2014

DOI: 10.1093/acprof:oso/9780199657018.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 12 November 2019

Adverse childhood experiences and brain development: neurobiological mechanisms linking the social environment to psychiatric disorders

Adverse childhood experiences and brain development: neurobiological mechanisms linking the social environment to psychiatric disorders

Chapter:
(p.249) Chapter 23 Adverse childhood experiences and brain development: neurobiological mechanisms linking the social environment to psychiatric disorders
Source:
A Life Course Approach to Mental Disorders
Author(s):

Katie A. McLaughlin

Margaret A. Sheridan

Charles A. Nelson, III

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199657018.003.0023

Adverse childhood experiences are robust determinants of psychiatric disorders with effects that persist across the life course. This chapter argues that childhood social and environmental experience weaves its way into the developing brain and exerts powerful effects on neural structure and function throughout childhood and into adulthood. These experiences ultimately have relevance for understanding population-level patterns of mental illness. Evidence linking adverse childhood experiences to patterns of brain development is reviewed, focusing on the role that disruptions in neurodevelopment play as a mechanism linking childhood social and environmental experience to the onset of mental disorders. Specifically addressed are the impact of maltreatment, institutional rearing, and childhood socio-economic status on brain development.

Keywords:   childhood adversity, brain development, neurodevelopment, maltreatment, institutionalization, socioeconomic status

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