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Exploring Personal Genomics$
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Joel T. Dudley and Konrad J. Karczewski

Print publication date: 2013

Print ISBN-13: 9780199644483

Published to Oxford Scholarship Online: December 2013

DOI: 10.1093/acprof:oso/9780199644483.001.0001

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Ancestry and genealogy

Ancestry and genealogy

(p.76) Chapter 5 Ancestry and genealogy
Exploring Personal Genomics

Joel T. Dudley

Oxford University Press

This chapter explores the genetics of human ancestry. Personal genomics's most intriguing and introspective aspect is the fact that each individual's genome contains the genetic footprints of ancestral lineage, going all the way to the roots of humankind itself. One of the challenges, then, that ‘genetic genealogy’ faces is the fact that genomes have a tendency to accumulate random mutational ‘noise’ and experience regular shuffling due to recombination — or the combining of the genetic material from one's mother and father. The chapter further discusses human ancestry by looking at the history of human migration patterns, particularly when modern humans migrated out of southern or eastern Africa some 200,000 years ago. The chapter reviews several global genetic mapping projects, such as HapMap, that aim to measure the genetic makeup of individuals from diverse ethnic and geographic populations. It is through this global ancestry analysis that one can finally pinpoint one's average ancestry on a world map.

Keywords:   human ancestry, personal genomics, genome, genetic footprints, ancestral lineage, genetic genealogy, human migration patterns, genetic mapping projects, HapMap, global ancestry analysis

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