The Clinical Neurobiology of the Hippocampus: An integrative view
Thorsten Bartsch
Abstract
The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical, and neurocomputational literature that presents basic mechanisms, theoretical models, and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented, and clinical approaches and concepts are scattered throughout various clinica ... More
The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical, and neurocomputational literature that presents basic mechanisms, theoretical models, and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines. This book explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches. The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural, and psychiatric symptoms and surpasses the ability to encode, store, and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia.
Keywords:
hippocampus,
clinical approaches,
hippocampal research,
therapeutic strategies,
clinical diseases,
psychopathological states,
depression
Bibliographic Information
| Print publication date: 2012 |
Print ISBN-13: 9780199592388 |
| Published to Oxford Scholarship Online: September 2012 |
DOI:10.1093/acprof:oso/9780199592388.001.0001 |
Authors
Affiliations are at time of print publication.
Thorsten Bartsch, editor
Department of Neurology, Consultant Neurologist, Head of the Memory Disorders Group, University Hospital of Schleswig Holstein, Kiel, Germany
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