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TobaccoScience, policy and public health$
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Peter Boyle, Nigel Gray, Jack Henningfield, John Seffrin, and Witold Zatonski

Print publication date: 2010

Print ISBN-13: 9780199566655

Published to Oxford Scholarship Online: September 2010

DOI: 10.1093/acprof:oso/9780199566655.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 24 May 2020

Smoking and ovarian cancer

Smoking and ovarian cancer

(p.503) Chapter 29 Smoking and ovarian cancer

Crystal N. Holick

Harvey A. Risch

Oxford University Press

This chapter reviews studies on the link between smoking and ovarian cancer. Cigarette smoke contains polycyclic aromatic hydrocarbons, N-nitrosamines, and other carcinogenic substances, and it is unknown if these constituents of the smoke reach the epithelium of the ovary to exert a local effect, as has been suggested elsewhere. Early studies reported no association between tobacco smoking and the risk of epithelial ovarian cancer, but more recent studies looking at the particular histologic varieties of ovarian cancer show fairly consistent associations between tobacco smoking and an increased risk of mucinous ovarian tumours. Ovarian cancer may very well be a heterogeneous disease with several distinct pathways that comprise the disease pathogenesis.

Keywords:   cigarette smoking, ovarian cancer, cancer risk, tobacco use

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