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TobaccoScience, policy and public health$
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Peter Boyle, Nigel Gray, Jack Henningfield, John Seffrin, and Witold Zatonski

Print publication date: 2010

Print ISBN-13: 9780199566655

Published to Oxford Scholarship Online: September 2010

DOI: 10.1093/acprof:oso/9780199566655.001.0001

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Tobacco carcinogenesis: mechanisms and biomarkers

Tobacco carcinogenesis: mechanisms and biomarkers

Chapter:
(p.127) Chapter 7 Tobacco carcinogenesis: mechanisms and biomarkers
Source:
Tobacco
Author(s):

Stephen S. Hecht

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199566655.003.0007

The indisputable relationship between the world's most widespread exogenous chemical carcinogen exposure — tobacco smoke — and cancer, provides a framework for a better understanding of cancer mechanisms in general, particularly the interaction between carcinogen exposure and host factors, and for the development of novel preventive and therapeutic strategies. Furthermore, the biomarkers that are developed in this research can be applied in the approaching era of tobacco product regulation. This chapter discusses the mechanisms of tumour induction by tobacco carcinogens and the status of tobacco carcinogen biomarkers.

Keywords:   tobacco smoke, cigarette smoke, cancer, tumour induction, tobacco carcinogens, biomarkers

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