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TobaccoScience, policy and public health$
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Peter Boyle, Nigel Gray, Jack Henningfield, John Seffrin, and Witold Zatonski

Print publication date: 2010

Print ISBN-13: 9780199566655

Published to Oxford Scholarship Online: September 2010

DOI: 10.1093/acprof:oso/9780199566655.001.0001

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The changing cigarette: chemical studies and bioassays

The changing cigarette: chemical studies and bioassays

Chapter:
(p.93) Chapter 6 The changing cigarette: chemical studies and bioassays
Source:
Tobacco
Author(s):

Ilse Hoffmann

Dietrich Hoffmann

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199566655.003.0006

This chapter discusses the identification of carcinogens and tumour promoters in tobacco smoke, changes in cigarette smoke composition with various design changes, and observations on cigarette smokers. Major modifications in the make-up of the commercial cigarette were introduced between 1950 and 1975, but since that time there have been few substantive changes toward a further reduction of the toxic and carcinogenic potential of cigarette smoke. A variety of changes in cigarette design and filtration have resulted in chemical changes in cigarette smoke, some of which have demonstrated decreased toxicity in animal assays. Changes in the agricultural, curing, and manufacturing processes of cigarettes have increased the amounts of tobacco-specific nitrosamines in cigarette smoke. These changes are considered to have contributed to the increase in adenocarcinoma of the lung observed over the past several decades.

Keywords:   cigarettes, smoking, carcinogens, tobacco smoke, cigarette smoke, cigarette smokers

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