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Sleep, Health and SocietyFrom Aetiology to Public Health$
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Francesco P. Cappuccio, Michelle A. Miller, and Steven W. Lockley

Print publication date: 2010

Print ISBN-13: 9780199566594

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780199566594.001.0001

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Sleep and respiratory diseases

Sleep and respiratory diseases

Chapter:
(p.141) Chapter 7 Sleep and respiratory diseases
Source:
Sleep, Health and Society
Author(s):

A. Xie

R. Kakkar

M.C. Teodorescu

L. Herpel

V Krishnan, and M. Teodorescu

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199566594.003.0007

Sleep has a significant impact on breathing through withdrawal of the wakefulness stimulus and alterations in muscle tone, ventilatory chemosensitivity, lung properties, and metabolic rate. Obstructive sleep apnea and sleep-related hypoventilation are highly prevalent and frequently unrecognized sleep breathing disorders, which have a significant impact on health. Among the many factors promoting their development, obesity represents the most important modifiable risk factor. There is increased recognition that a dual interaction between sleep/sleep disorders and chronic lung disease exists. On the one hand, there is increased prevalence of globally disturbed sleep, insomnia, and restless legs syndrome in chronic lung disease. On the other hand, sleep is a vulnerable time for these patients and there is data to suggest worse respiratory outcomes and quality of life in patients with coexistenting sleep disorders. Many gaps remain in our knowledge of the nature of these interactions, their underlying mechanisms, and implications for these already compromised populations.

Keywords:   breathing control, sleep apnea, sleep hypoventilation, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary hypertension

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