Serious illness and impending death focus one's attention on ultimate concerns, and these are precisely the issues that religion has always addressed. In short, scientific medicine may be able to provide us with the means to live longer and healthier lives, but it is utterly powerless to offer us any meaning to live for. But that is precisely what spiritual care offers and, therefore, why it is so crucial in supportive dementia care. This chapter discusses the challenges of discussing the spiritual dimension of supportive care for persons with dementia and their carers, the complication posed by the many different spiritual paths people currently follow, and basic principles of supportive spiritual care.