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Supportive care for the person with dementia$
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Julian Hughes, Mari Lloyd-Williams, and Greg Sachs

Print publication date: 2009

Print ISBN-13: 9780199554133

Published to Oxford Scholarship Online: November 2011

DOI: 10.1093/acprof:oso/9780199554133.001.0001

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Pharmacological management of neuropsychiatric symptoms in people with dementia

Pharmacological management of neuropsychiatric symptoms in people with dementia

Chapter:
(p.105) Chapter 12 Pharmacological management of neuropsychiatric symptoms in people with dementia
Source:
Supportive care for the person with dementia
Author(s):

Clive Ballard

Dag Aarsland

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199554133.003.0012

This chapter summarizes the evidence of benefits and harms related to antipsychotic drugs in people with Alzheimer's disease (AD), and reviews pharmacological approaches for the management of neuropsychiatric symptoms in these patients. Where the evidence is incomplete, it offers an interpretation to help guide clinical decision-making. The chapter focuses heavily on treatment issues in AD, predominantly because of the very limited evidence base related to the treatment of other dementias. Non-pharmacological approaches are likely to be equally applicable across all dementias (although this has not been established in clinical trials), but there are specific risks associated with antipsychotic medication in vascular dementia and dementia with Lewy bodies, which highlight the priority of developing evidence based pharmacological approaches for the treatment of neuropsychiatric symptoms in these patient groups.

Keywords:   Alzheimer's disease, antipsychotic drugs, dementia, pharmacological approaches

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