Jump to ContentJump to Main Navigation
Statistics and Informatics in Molecular Cancer Research$
Users without a subscription are not able to see the full content.

Carsten Wiuf and Claus L. Andersen

Print publication date: 2009

Print ISBN-13: 9780199532872

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780199532872.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 24 August 2019

Methods for DNA copy number derivations

Methods for DNA copy number derivations

Chapter:
(p.25) 2 Methods for DNA copy number derivations
Source:
Statistics and Informatics in Molecular Cancer Research
Author(s):

Cameron Brennan

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199532872.003.0002

Chromosomal aberrations are a common form of mutation in cancer. Copy number profiling of tumour-derived DNA has proven to be a productive starting point for identifying novel cancer-relevant genes and molecularly-defined tumour subclasses. Generating and interpreting copy number draws on intuitively simple ideas which are complicated when reduced to practice. This chapter presents a range of issues relevant to choosing a profiling platform, designing custom arrays, reducing noise, and identifying artefacts or population polymorphisms which can mimic cancer aberrations. Specific methods and examples highlight the problems of segmentation/change-point determination, multi-sample analysis, hierarchical clustering, and high-resolution mapping of intragenic copy number aberrations.

Keywords:   segmentation, copy number aberration, copy number variation, cancer genomics, tumour-derived DNA

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .