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Ancestral Sequence Reconstruction$
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David A Liberles

Print publication date: 2007

Print ISBN-13: 9780199299188

Published to Oxford Scholarship Online: September 2008

DOI: 10.1093/acprof:oso/9780199299188.001.0001

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Coarse projections of the protein-mutational fitness landscape

Coarse projections of the protein-mutational fitness landscape

Chapter:
(p.80) CHAPTER 7 Coarse projections of the protein-mutational fitness landscape
Source:
Ancestral Sequence Reconstruction
Author(s):

F. Nicholas Braun

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199299188.003.0007

The extant phylogenetic variability of a given protein contains information about its underlying sequence-fitness landscape, potentially of value to ancestral reconstruction. In extracting such information, it is pertinent to focus on coarse-grained traits of sequence with strong physicochemical bearing on the protein's phenotype. This chapter uses phylogenetic data to stake out roughly the landscape for a protein component of spider silk.

Keywords:   physicochemical constraints, design pressure, coarse-grained traits, genotype-phenotype mapping, phylogenetic variability, viable sequence space, deleterious sequence space

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