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Ancestral Sequence Reconstruction$
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David A Liberles

Print publication date: 2007

Print ISBN-13: 9780199299188

Published to Oxford Scholarship Online: September 2008

DOI: 10.1093/acprof:oso/9780199299188.001.0001

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Using ancestral sequence inference to determine the trend of functional divergence after gene duplication

Using ancestral sequence inference to determine the trend of functional divergence after gene duplication

Chapter:
(p.117) CHAPTER 11 Using ancestral sequence inference to determine the trend of functional divergence after gene duplication
Source:
Ancestral Sequence Reconstruction
Author(s):

Xun Gu

Ying Zheng

Yong Huang

Dongping Xu

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199299188.003.0011

This chapter presents a new approach to functional divergence analysis with the combination of ancestral sequence inference, using the family of animal G-protein subunits as an example. Using the method, the evolutionary trends of two types of functional divergence of amino acid residues after gene duplication are traced. These pieces of evolutionary information are useful for making testable hypotheses about functional divergence between protein subfamilies, such as subtypes of G-protein subunits, which can be verified by further experimentation.

Keywords:   functional divergence analysis, G-protein subunits, amino acid, evolution

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