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Venous Thromboembolism in Advanced DiseaseA clinical guide$
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Simon I R Noble, Miriam J Johnson, and Agnes Y Y Lee

Print publication date: 2008

Print ISBN-13: 9780199232048

Published to Oxford Scholarship Online: November 2011

DOI: 10.1093/acprof:oso/9780199232048.001.0001

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Pathogenesis of venous thromboembolism in cancer

Pathogenesis of venous thromboembolism in cancer

(p.29) Chapter 3 Pathogenesis of venous thromboembolism in cancer
Venous Thromboembolism in Advanced Disease

Sarah J. Lewis

Oxford University Press

This chapter examines the pathogenesis of venous thromboembolism (VTE) in patients with cancer. It explains that patients with cancer are more likely to develop VTE than those without. This is because the coagulation cascade is activated by factors related both directly and indirectly to the tumour, and all parts of Virchow's triad may be involved with the development of thrombosis. Despite the progress in thrombosis research, many questions remain unanswered including the role of primary thromboprophylaxis and the possibility of adjuvant anticoagulation as an anticancer therapy.

Keywords:   VTE, cancer, pathogenesis, coagulation cascade, tumour, Virchow's triad, thrombosis, thromboprophylaxis, adjuvant anticoagulation, anticancer therapy

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