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Statistical Theory and Methods for Evolutionary Genomics$
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Xun Gu

Print publication date: 2010

Print ISBN-13: 9780199213269

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780199213269.001.0001

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Gene Pleiotropy and Evolution of Protein Sequence

Gene Pleiotropy and Evolution of Protein Sequence

(p.143) 8 Gene Pleiotropy and Evolution of Protein Sequence
Statistical Theory and Methods for Evolutionary Genomics

Xun Gu

Oxford University Press

The concept of gene pleiotropy may play a key role in developing an integrated view of protein evolution. Although the capacity of a gene that may affect multiple phenotypic characters has been used to explain many biological phenomena, little has been known about the extent of pleiotropy at the genome level. Based on the premise that links between gene pleiotropy and the dimensionality of organismal fitness, the author of this book has provided a feasible statistical framework to estimate the degree of gene pleiotropy. This chapter discusses this issue.

Keywords:   gene pleiotropy, protein evolution, protein sequences, genome

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