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Statistical Theory and Methods for Evolutionary Genomics$
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Xun Gu

Print publication date: 2010

Print ISBN-13: 9780199213269

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780199213269.001.0001

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Tissue‐Driven Hypothesis of Genomic Evolution

Tissue‐Driven Hypothesis of Genomic Evolution

(p.127) 7 Tissue‐Driven Hypothesis of Genomic Evolution
Statistical Theory and Methods for Evolutionary Genomics

Xun Gu

Oxford University Press

Understanding the underlying regulatory mechanism is a fundamental step to exploring the emergence of genome complexity. An important issue is the role of tissue-specific factors in genomic evolution. Several studies have suggested that tissue-specific constraints may generate among tissue variation of expression divergence between humans and chimpanzees, between humans and mice, or between fruitflies. Duret and Mouchiroud showed that the rate of protein divergence was negatively associated with the tissue broadness of gene expression. This chapter first discusses the tissue-driven hypothesis, based on an explicit evolutionary model for providing testable predictions. This theory claims that stabilizing selections for both expression and sequence divergences may be affected simultaneously by common tissue factors. It then addresses an interesting problem about the expression evolution in the human brain since the separate development of humans and chimpanzees.

Keywords:   tissue-driven hypothesis, genomic evolution, tissue factors, human brain, tissue expression, sequence divergence, chimpanzee

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