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Statistical Theory and Methods for Evolutionary Genomics$
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Xun Gu

Print publication date: 2010

Print ISBN-13: 9780199213269

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780199213269.001.0001

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Expression between Duplicate Genes: Genome‐Wide Analysis

Expression between Duplicate Genes: Genome‐Wide Analysis

(p.113) 6 Expression between Duplicate Genes: Genome‐Wide Analysis
Statistical Theory and Methods for Evolutionary Genomics

Xun Gu

Oxford University Press

Expression divergence between duplicate genes has long been a subject of great interest to geneticists and evolutionists. Ohno proposed that expression divergence is the first step in the functional divergence between duplicate genes and thereby increases the chance of retention of duplicate genes in a genome. Further, advances in molecular biology in the 1970s and 1980s provided a much better understanding of the molecular basis of expression divergence between duplicate genes. The availability of completely sequenced genomes and microarray gene expression and other functional genomic data have stimulated many studies on these questions. This chapter introduces these results.

Keywords:   expression divergence, duplicate genes, gene duplication, Ohno, functional divergence

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