Jump to ContentJump to Main Navigation
Dendrites$
Users without a subscription are not able to see the full content.

Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2016

Print ISBN-13: 9780198745273

Published to Oxford Scholarship Online: May 2016

DOI: 10.1093/acprof:oso/9780198745273.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 21 November 2019

Molecular signaling during plasticity of dendritic spines

Molecular signaling during plasticity of dendritic spines

Chapter:
(p.581) Chapter 20 Molecular signaling during plasticity of dendritic spines
Source:
Dendrites
Author(s):

Ryohei Yasuda

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198745273.003.0020

Intracellular signaling in dendrites of pyramidal neurons is responsible for synaptic plasticity related to learning and memory. It is mediated by a biochemical network consisting of hundreds of signaling molecules extensively connecting to each other. The signaling processes for synaptic plasticity are initiated in a dendritic spine and targeted to multiple subcellular compartments in the stimulated spine and surrounding dendritic segment. This in turn causes a rapid modification of the structure and function of the stimulated spine. Some signals spread over much longer distances, influencing the properties of their parent dendritic branch or the nucleus to regulate gene transcription. Due to the complicated morphology of dendrites, the biochemical reaction is compartmentalized in different length scales, determining the length scales of different forms of synaptic plasticity and meta-plasticity. The recent development of optical techniques has allowed researchers to image signaling activity in dendrites at the single-spine level and this provided many insights into how the spatio-temporal dynamics of intracellular signaling is organized during synaptic plasticity.

Keywords:   intracellular signaling, synaptic plasticity, dendrites, spines, signaling molecules, gene transcription

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .