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Dendrites$
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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2016

Print ISBN-13: 9780198745273

Published to Oxford Scholarship Online: May 2016

DOI: 10.1093/acprof:oso/9780198745273.001.0001

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Spine calcium signaling

Spine calcium signaling

Chapter:
(p.325) Chapter 11 Spine calcium signaling
Source:
Dendrites
Author(s):

Adam Carter

Bernardo Sabatini

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198745273.003.0011

Spines are specialized cellular compartments found at high density on the dendrites of many neurons. Glutamatergic synapses are made onto spines, which house much of the machinery needed to read out synaptic activity. By providing a diffusionally isolated signaling compartment, spines allow neighboring synapses to operate independently. Stimulus-evoked increases in spine calcium trigger many forms of synaptic plasticity and can influence local excitability and morphology. This chapter focuses on the mechanisms of calcium handling and signaling within individual spines.

Keywords:   dendrite, spine, synapse, calcium, signaling, plasticity, excitability

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