Jump to ContentJump to Main Navigation
Making Medical Knowledge$
Users without a subscription are not able to see the full content.

Miriam Solomon

Print publication date: 2015

Print ISBN-13: 9780198732617

Published to Oxford Scholarship Online: June 2015

DOI: 10.1093/acprof:oso/9780198732617.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 January 2020

The Fallibility of Evidence-Based Medicine

The Fallibility of Evidence-Based Medicine

Chapter:
(p.133) 6 The Fallibility of Evidence-Based Medicine
Source:
Making Medical Knowledge
Author(s):

Miriam Solomon

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198732617.003.0006

Evidence-based medicine is designed to minimize bias. Several philosophers have argued that the methods of evidence-based medicine do not eliminate the possibility of bias and error. This chapter considers these arguments, and finds them less compelling than the empirical findings of John Ioannidis and others that randomized controlled trials and even meta-analyses are less replicable than expected. Moreover, observational trials are much closer than expected to randomized controlled trials in external validity. The quality of clinical trials is multidimensional and not appropriately captured by the usual linear hierarchy of evidence. Possible solutions for various sources of bias and error are also considered.

Keywords:   evidence-based medicine, EBM, meta-analysis, external validity, evidence hierarchy, hierarchy of evidence, randomized controlled trials, RCT, observational trials, John Ioannidis

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .